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ABOUT MENOPAUSE WHAT IS PREMARIN? HOW TO USE SAFETY INFORMATION

HOW TO USE

On this page:

How to apply

What dose

Safety information

How to apply

PREMARIN Vaginal Cream comes with its own applicator to help you apply the cream.

Follow these step-by-step instructions to properly apply PREMARIN Vaginal Cream and learn how to clean the applicator:

Step 1
Remove cap from tube.
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Step 2
Screw nozzle end of applicator onto tube.
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Step 3
Gently squeeze tube from the bottom to force sufficient cream into the barrel to provide the prescribed dose.
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Step 4
Unscrew applicator from tube.
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Step 5
To release medication, gently insert the applicator into the vagina and press the plunger downward.
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Step 6
TO CLEANSE: Pull plunger to remove it from barrel. Wash with mild soap and warm water.
DO NOT BOIL.
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Please refer to the package insert for the full application instructions.

What dose

You should follow the dosage regimen prescribed by your doctor.

Tip

Apply PREMARIN Vaginal Cream at about the same time every day to help you remember to apply it regularly.

What if I miss a dose?

If you miss a dose of PREMARIN Vaginal Cream, use it as soon as you remember. However, if it is almost time to apply your next dose, skip the dose you missed and only take your next scheduled dose. Do not take two doses at the same time.

What if I take too much?

If you think you, or a person you are caring for, have taken too much PREMARIN Vaginal Cream, contact a healthcare professional, hospital emergency department, regional poison control center, or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Overdosage with estrogens may cause nausea and vomiting, breast discomfort, fluid retention, bloating, or vaginal bleeding in women. There is no specific antidote, and further treatment, if necessary, should be symptomatic.

Overdosage may result in a period of amenorrhea (lack of menses) of a variable length and may be followed by irregular menses for several cycles. No cases of overdosage in male patients have been reported.

How do I store PREMARIN Vaginal Cream?

PREMARIN Vaginal Cream should be stored at room temperature (15°–30°C).

Keep out of reach and sight of children.

Are there any interactions with PREMARIN Vaginal Cream?

Tell your doctor or pharmacist if you are taking any other medications, including prescription medications, over-the-counter medications, vitamins, or herbal products (such as St. John’s Wort).  Some medications, such as medications for high blood pressure, diabetes, blood clots, sleeping, anxiety, seizures, pain-relief, and tuberculosis, may affect how PREMARIN Vaginal Cream works. PREMARIN Vaginal Cream may also affect how other medicines work.

You should also tell your doctor or pharmacist if you use latex or rubber diaphragms or cervical caps.

Are there any side effects with PREMARIN Vaginal Cream?

Side effects are possible when using PREMARIN Vaginal Cream. They can include:

If any of these affects you severely, tell your doctor, nurse, or pharmacist.

Click here for important safety information

© 2025 Pfizer Canada ULC
Kirkland, Quebec
H9J 2M5

PREMARIN ® Pfizer Canada ULC

PP-PVC-CAN-0056-EN